Past week, the first SETAC/iEOS joint Focused Topic Meeting on Environmental and (eco)toxicological omics and epigenetics was held in Ghent. Prof. Karel De Schamphelaere and Dr. Jana Asselman co-organized the meeting together with members from academia, government and industry. The four day meeting brought together 120 participants from across the globe. State of the art science, technology and regulatory perspectives were presented in 48 platform presentations and 34 posters. The meeting concluded with a challenging panel debate on how epigenetic effects can be addressed in regulatory frameworks and risk assessment.